The opioid crisis, fueled by the greed of big pharma pushing highly addictive and potent painkillers, has significantly impacted the United States, particularly states like Ohio. It has evolved into an epidemic, ensnaring innocent people in addiction as they seek medication that they know could be prescribed to them, provided they approach the right doctor. As long as drug companies continue to profit and their drugs are prescribed, they appear indifferent to the destructive consequences they are causing.
Pain Hustlers is based on a true story about a single mother, Liza Drake (Emily Blunt), living below the poverty line, and struggling to support her and her daughter Phoebe (Chloe Coleman). Grasping at straws, she comes across a job opening in pharmaceutical sales and, with the help of Pete Brenner (Chris Evans), gets the job. However, upon starting, she discovers that the company is on the brink of collapse. Undeterred, she sets out to convince local doctors to switch to their drug, Lonafen, but finds it nearly impossible as other companies have already sunk their claws into local scene. After persisting, she finally makes a breakthrough, gets her first script and single-handedly saves the company.
The company experiences a boom as Lonafen gains popularity. Eager to capitalize on this success, the company recruits a horde of sales reps and embarks on a mission to dominate as many small Florida doctors' offices as possible, ultimately making millions. However, the gleaming success starts to dim as Liz discovers that Lonafen is highly addictive, wreaking havoc on thousands of individuals and families. Determined to rectify her wrongs, Liz takes the initiative to approach the FBI, providing the evidence necessary to shut down their company. This action leads to the imprisonment of herself, Pete, and their boss.